The IκB-Protein BCL-3 Controls MAPK Activity by Promoting TPL-2 Degradation in the Nucleus.
P. E. Collins, D. Somma, D. Kerrigan, F. Herrington, K. R. Keeshan, R. J. Nibbs, R. J. Carmody
This study shows BCL-3 promotes TPL-2 degradation in the nucleus, reducing MAPK activity and increasing the threshold for TLR-induced inflammation.
bioRxiv · Jul 20, 2018Immunology