The white matter is a pro-differentiative microenvironment for glioblastoma
L. J. Brooks, M. P. Clements, J. J. Burden, D. Kocher, L. Richards, S. Castro Devesa, M. Woodberry, M. Ellis, L. Zakka, Z. Jaunmuktane, S. Brandner, G. Morrison, S. M. Pollard, P. B. Dirks, S. Marguerat, S. Parrinello
This study identifies the white matter as a differentiative niche for glioblastomas, showing that tumour cells in contact with it acquire pre-oligodendrocyte-like fate, leading to reduced proliferation and invasion.
bioRxiv · Nov 14, 2020 · PreprintCancer Biology