M. Ellis

Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates

This study shows that mucosal adenoviral-vectored vaccines provide durable protection against XBB.1.16 infection in nonhuman primates, outperforming intramuscular boosting in reducing virus replication in both upper and lower airways.

Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity

This study examines how SARS-CoV-2 booster vaccines affect antibody profiles in myeloma patients, finding improved binding but not neutralization against variants.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron

This study compares B cell responses and protection against Omicron after boosting vaccinated macaques with mRNA-1273 or mRNA-Omicron vaccines, finding comparable immunity and protection.

Mapping prion pathology in mice using quantitative imaging: an MRI study

The paper uses MRI techniques to detect early prion disease changes in mice, identifying significant alterations in brain regions before clinical symptoms appear.

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

Can Chemical Exchange Saturation Transfer (CEST MRI) be used as biomarker of disease progression in Prion Disease?

This study shows that CEST MRI can detect early pathological changes in prion disease before structural or clinical signs, with significant correlations between CEST metrics and histopathological findings.

The white matter is a pro-differentiative microenvironment for glioblastoma

This study identifies the white matter as a differentiative niche for glioblastomas, showing that tumour cells in contact with it acquire pre-oligodendrocyte-like fate, leading to reduced proliferation and invasion.

Guiding dose selection of monoclonal antibodies using a new parameter (AFTIR) for characterizing ligand binding systems

The paper introduces a new metric, AFTIR, to guide monoclonal antibody dose selection by simplifying complex target-mediated drug disposition models into four key parameters.