The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro)
A. Ebrahim, B. T. Riley, D. Kumaran, B. Andi, M. R. Fuchs, S. McSweeney, D. A. Keedy
This study reports high-resolution crystal structures of SARS-CoV-2 Mpro at various temperatures and humidity, revealing temperature-dependent conformational changes and structural features relevant to antiviral drug development.
bioRxiv · May 3, 2021Biophysics