Discovery of biaryl macrocyclic peptides with C-terminal β-amino-α-keto acid groups
D. T. Nguyen, L. Zhu, D. L. Gray, T. Woods, C. Padhi, K. M. Flatt, D. A. Mitchell, W. A. van der Donk
This study discovers a new class of macrocyclic peptides by mining genomes for biosynthetic gene clusters, revealing novel enzymatic modifications involving a cytochrome P450 and other enzymes.
bioRxiv · Oct 30, 2023Biochemistry