L. Zhu

Neuroprotective Mechanism of Ribisin A on H 2 O 2 -induced PC12 cell injury model

This study investigates how Ribisin A protects PC12 cells from H2O2-induced injury by enhancing antioxidant activity, reducing inflammation, and modulating the ERK/CREB signaling pathway.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Cryo-EM structure of monomeric CXCL12-bound CXCR4 in active state

This paper presents a cryo-EM structure of CXCL12-bound CXCR4 in an active state, revealing key interactions that stabilize the ligand-receptor complex.

Population size interacts with reproductive longevity to shape the germline mutation rate

The paper examines how reproductive longevity interacts with population size to shape germline mutation rates, finding that longer reproductive ages reduce mutation rates per year in sperm and eggs.

High-Throughput Evolution Unravels Landscapes of High-Level Antibiotic Resistance Induced by Low-Level Antibiotic Exposure

This study uses high-throughput evolution to explore antibiotic resistance landscapes in E. coli exposed to low-level antibiotics, identifying key mutations and developing predictive models.

High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

This paper introduces LFMNR, a method for high-fidelity 3D reconstruction of biological dynamics using physics-informed neural representations and meta-learning, achieving improved resolution and speed.

Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments

This study introduces METRIC, a deep-learning method that uses gut microbiome data to correct random errors in self-reported dietary assessments, showing effectiveness in simulated and real-world datasets.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

Structural Insights into Dopamine Receptor-Ligand Interactions: From Agonists to Antagonists

This study investigates dopamine receptor-ligand interactions using molecular modeling, revealing binding modes and stability of agonists and antagonists at D1R and D5R.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Discovery of biaryl macrocyclic peptides with C-terminal β-amino-α-keto acid groups

This study discovers a new class of macrocyclic peptides by mining genomes for biosynthetic gene clusters, revealing novel enzymatic modifications involving a cytochrome P450 and other enzymes.

Diet composition drives tissue-specific intensity of murine enteric infections

This study shows that diet composition affects tissue-specific susceptibility to enteric infections in mice, with fiber-rich diets increasing pathogen burden in some cases.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

PRO-LDM: Protein Sequence Generation with a Conditional Latent Diffusion Model

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

Semantic redundancy-aware implicit neural compression for multidimensional biomedical image data

This paper introduces SINCS, a compression method for multidimensional biomedical images that improves efficiency and quality by leveraging semantic redundancy and saliency maps.

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.

Structural basis for lipid transfer by the ATG2A-ATG9A complex

This study determines the cryo-EM structures of ATG2A and ATG2A-ATG9A complexes, revealing their roles in lipid transfer during autophagosome formation.

Differences in Hepatocellular Iron Metabolism Underlie Sexual Dimorphism in Hepatocyte Ferroptosis

This study identifies sex differences in hepatocyte ferroptosis, showing males are more susceptible due to differences in iron metabolism and FSP1 regulation.

Spatiotemporal Control of Genomics and Epigenomics by Ultrasound

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation

The paper compares four E. coli ABCF paralogs to determine their distinct roles in mRNA translation using biochemical and biophysical assays.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

Cryo-EM structures of the human G-protein coupled receptor 1 (GPR1) - Gi protein complexes bound to the full-length chemerin and to its C-terminal nonapeptide

The paper reports cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and its C-terminal nonapeptide, revealing a 'two-site' interaction model and structural similarities to CMKLR1-Gi complexes.

Spatio-temporal variation of bacterial community structure in two intertidal sediment types of Jiaozhou Bay

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

Effect of Intermittent Pneumatic Compression on Preventing Deep Vein Thrombosis Using Microfluidic Vein Chip

The paper develops a microfluidic vein chip to simulate IPC effects and identifies optimal parameters for DVT prevention.

Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

This study uses simulations and experiments to show that diblock polypeptides form interfacial environments due to hydrophilic-hydrophobic residue distribution, affecting condensate stability and hydrogen bonding.

Adaptive-learning physics-aware light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

Rational design of immune gene therapy combinations via in vivo CRISPR activation screen of tumor microenvironment modulators

This study uses in vivo CRISPR activation screens to identify immunostimulatory factors that enhance anti-tumor immunity and develop effective gene therapy combinations.

Genome mining unveils a class of ribosomal peptides with two amino termini

The paper identifies a new class of ribosomal peptides, daptides, with two amino termini, discovered through genome mining and characterized experimentally.

A remarkable transformation catalyzed by a domain-of-unknown-function 692 during the biosynthesis of a new RiPP natural product

This study identifies a new reaction catalyzed by DUF692, a posttranslational modification enzyme, revealing its role in forming a macrocycle and other chemical modifications in a RiPP natural product.