Mechanistic basis for decreased antimicrobial susceptibility in a clinical isolate of Neisseria gonorrhoeae possessing a mosaic-like mtr efflux pump locus
C. Rouquette-Loughlin, J. L. Reimche, J. T. Balthazar, V. Dhulipala, K. Gernert, E. Kersh, C. Pham, K. Pettus, A. J. Abrams, D. L. Trees, Cyr, S. St, W. M. Shafer
The paper investigates how a mosaic-like mtr efflux pump locus in Neisseria gonorrhoeae reduces antimicrobial susceptibility through promoter mutations and amino acid changes in MtrD.
bioRxiv · Oct 22, 2018Microbiology