Author

C. Pham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Immunology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

D. Li· 3 shared C. Martin· 2 shared C. Mouffle· 2 shared E. Foppen· 2 shared E. Montalban· 2 shared J. Castel· 2 shared R. Hassouna· 2 shared A. Ansoult· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

D. Li

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells

I. Lee, I. Ling, S. Verma, W. Blanche, C. Pham, P. Kendall

This study shows CD55 supports MZ B cell survival and regulates TLR9 signaling, with loss of CD55 leading to reduced survival and increased apoptosis in aged mice.

bioRxiv · Mar 1, 2024Immunology

Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis

C. Pham, Y. Komaki, A. Deas-Just, B. Le Gac, C. Mouffle, C. Franco, A. Chaperon, V. Vialou, T. Tsurugizawa, B. Cauli, D. Li

This study shows astrocyte aquaporin 4 mediates a tonic water efflux that maintains brain water homeostasis, astrocyte volume, and extracellular space remodeling.

bioRxiv · Oct 3, 2023Physiology

Dual role of striatal astrocytes in behavioral flexibility and metabolism in the context of obesity

E. Montalban, D. Herrera Moro Chao, A. Ansoult, C. Pham, A. Contini, J. Castel, R. Hassouna, M. Hardonk, A. Petitbon, E. Foppen, G. Gangarossa, P. Trifilieff, D. Li, S. Luquet, C. Martin

This study shows that striatal astrocytes regulate behavioral flexibility and metabolism in obesity through chemogenetic manipulation in mice.

bioRxiv · Mar 21, 2023 · PreprintPhysiology

Redox-controlled structural reorganization and flavin strain within the ribonucleotide reductase R2b-NrdI complex monitored by serial femtosecond crystallography

J. John, O. Aurelius, V. Srinivas, I.-S. Kim, A. Bhowmick, P. S. Simon, M. Dasgupta, C. Pham, S. Gul, K. D. Sutherlin, P. Aller, A. Butryn, A. M. Orville, M. H. Cheah, S. Owada, , M. Hogbom

The paper uses serial femtosecond crystallography to study redox-induced structural changes in the R2b-NrdI complex, revealing flavin strain and its role in superoxide generation.

bioRxiv · Apr 14, 2022Biochemistry

Hypothalamic astrocyte control systemic glucose metabolism and energy balance via regulation of extra-synaptic glutamate signaling

D. H. M. Chao, M. K. Kirchner, C. Pham, E. Foppen, R. G. P. Denis, J. Castel, C. Morel, E. Montalban, R. Hassouna, L.-C. Bui, J. Renault, C. Mouffle, C. Garcia-Caceres, M. H. Tschop, D. Li, , S. H. Luquet

This study shows that hypothalamic astrocytes regulate systemic glucose metabolism and energy balance through extra-synaptic glutamate signaling, offering new targets for obesity treatment.

bioRxiv · Feb 16, 2022 · PreprintPhysiology

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

T. Lebratti, Y. S. Lim, A. Cofie, P. Andhey, X. Jiang, J. Scott, M. R. Fabbrizi, A. N. Ozantürk, C. Pham, R. Clemens, M. Artyomov, M. Dinauer, H. Shin

This study identifies a type I IFN-neutrophil-IL-18 axis driving immunopathology in genital HSV-2 infection.

bioRxiv · Dec 20, 2020Immunology

Mechanistic basis for decreased antimicrobial susceptibility in a clinical isolate of Neisseria gonorrhoeae possessing a mosaic-like mtr efflux pump locus

C. Rouquette-Loughlin, J. L. Reimche, J. T. Balthazar, V. Dhulipala, K. Gernert, E. Kersh, C. Pham, K. Pettus, A. J. Abrams, D. L. Trees, Cyr, S. St, W. M. Shafer

The paper investigates how a mosaic-like mtr efflux pump locus in Neisseria gonorrhoeae reduces antimicrobial susceptibility through promoter mutations and amino acid changes in MtrD.

bioRxiv · Oct 22, 2018Microbiology