HssS activation by membrane heme defines a paradigm for 2-component system signaling in Staphylococcus aureus.
D. Lechardeur, V. Saillant, L. Morey…·P. Arnoux
This study identifies how heme binds to the HssS sensor in Staphylococcus aureus, triggering a signaling cascade that activates heme efflux to prevent toxicity.