Molecular basis of selective cytokine signaling inhibition by antibodies targeting a shared receptor
J. K. Fields, K. Kihn, G. S. Birkedal, E. H. Klontz, K. Sjöström, S. Günther, R. Beadenkopf, G. Forsberg, D. Liberg, G. A. Snyder, D. Deredge, E. J. Sundberg
This study shows that antibodies targeting IL-1RAcP can selectively block signaling by different IL-1 family cytokines based on distinct epitopes they engage.
Frontiers in Immunology · Dec 24, 2021Peer-reviewedImmunology