Author

D. Deredge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Organism:human· 3 Organism:bacteria (other)· 2 Assay:protein structure· 2 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

E. H. Klontz· 2 shared G. A. Snyder· 2 shared J. O. Obi· 2 shared K. Kihn· 2 shared A. Diantonio· 1 shared A. E. Sestok· 1 shared A. Gershenson· 1 shared A. H. Aytenfisu· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

E. H. Klontz

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.

E. Klontz, J. O. Obi, Y. Wang, G. Glendening, J. Carr, C. Tsibouris, S. Buddula, S. Nallar, A. Soares, D. Beckett, J. S. Redzic, E. Eisenmesser, C. Palm, K. Schmidt, A. Scudder, , G. A. Snyder

The paper reports the crystal structure of Acinetobacter baumannii TIR domain and its NAD+ hydrolase activity, showing conformational changes and kinetic effects upon substrate binding.

bioRxiv · May 19, 2023 · PreprintBiochemistry

The conformational landscape of a serpin N-terminal subdomain facilitates folding and in-cell quality control

U. Kaur, K. C. Kihn, H. Ke, W. Kuo, L. M. Gierasch, D. N. Hebert, P. L. Wintrode, D. Deredge, A. Gershenson

This paper investigates how the N-terminal subdomain of serpin 1-antitrypsin (AAT) influences folding and in-cell quality control by maintaining a dynamic conformational landscape.

bioRxiv · Apr 24, 2023 · PreprintBiophysics

Biochemical and structural characterization of the fused Bacteroides fragilis NFeoAB domain reveals a role for FeoA

A. E. Sestok, J. B. Brown, J. O. Obi, S. M. O'Sullivan, E. D. Garcin, D. Deredge, A. T. Smith

This study characterizes the Bacteroides fragilis NFeoAB fusion protein, revealing FeoA's role in stabilizing the GTP-bound form of FeoB through nucleotide-dependent interactions.

bioRxiv · Sep 29, 2021 · PreprintBiochemistry

Insights into substrate recognition and specificity for IgG by Endoglycosidase S2

A. H. Aytenfisu, D. Deredge, E. H. Klontz, J. Du, E. Sundberg, A. MacKerell

This study uses molecular dynamics simulations to model how EndoS2 interacts with IgG, revealing structural insights into its substrate recognition and catalytic mechanism.

bioRxiv · May 24, 2021Biophysics

Molecular basis of selective cytokine signaling inhibition by antibodies targeting a shared receptor

J. K. Fields, K. Kihn, G. S. Birkedal, E. H. Klontz, K. Sjöström, S. Günther, R. Beadenkopf, G. Forsberg, D. Liberg, G. A. Snyder, D. Deredge, E. J. Sundberg

This study shows that antibodies targeting IL-1RAcP can selectively block signaling by different IL-1 family cytokines based on distinct epitopes they engage.

bioRxiv · May 7, 2021Immunology

Development and validation of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3)

C. N. Smith, K. Kihn, Z. A. Williamson, Y. Chernyavskyay, K. M. Chow, L. B. Hersh, K. V. Korotkov, D. Deredge, J. S. Blackburn

This paper develops and validates nanobodies that specifically target PRL-3, showing high specificity over PRL-1 and PRL-2 and providing tools to study PRL-3 function in cancer.

bioRxiv · Oct 2, 2020 · PreprintBiochemistry