Structural basis of cowpox evasion of NKG2D immunosurveillance
E. Lazear, M. M. Sun, X. Wang, T. L. Geurs, C. A. Nelson, J. A. Campbell, D. Lippold, A. S. Krupnick, R. S. Davis, L. N. Carayannolpoulos, A. R. French, D. H. Fremont
This study identifies OMCP as a cowpox virus protein that directly binds NKG2D to evade immune detection, revealing structural insights into its high-affinity interaction and zoonotic potential.
bioRxiv · Oct 7, 2019 · PreprintImmunology