Metabolization of alpha-D-carba-glucosamine in vivo generates antimetabolites of cell wall precursors
M. Mund, S. Friz, A. Esser, D. Matzner, B. Babczyk, D. Menche, H. Broetz-Oesterhelt, C. Mayer, G. Mayer
This study shows that CGlcN is metabolized into carba-metabolites that inhibit bacterial cell wall synthesis, revealing a new antimetabolite mechanism of action.
bioRxiv · Feb 8, 2023 · PreprintMicrobiology