Endosomal LRBA regulates the endo-lysosomal pathway
V. Szentgyoergyi, L. M. Lueck, D. Overwijn, N. N. Zoeller, M. Hondele, A. Spang, S. Bakhtiar
This study identifies LRBA's role in regulating the endosomal-lysosomal pathway by controlling Rab4+ endosome traffic, leading to enlarged endolysosomes in LRBA-deficient patients.
bioRxiv · Feb 7, 2024 · PreprintImmunology