A. Spang

Arrestin recognizes GPCRs independently of the receptor state

This study shows arrestin2 binds to the β1-adrenergic receptor independently of receptor conformation or ligand type, driven by a conformational change in arrestin induced by a phosphopeptide.

Chimeric Origins and Dynamic Evolution of Central Carbon Metabolism in Eukaryotes

The paper investigates the evolutionary origins of central carbon metabolism in eukaryotes, revealing a chimeric gene repertoire with contributions from Asgardarchaeota and Alphaproteobacteria.

Coordination between ESCRT function and Rab conversion during endosome maturation

The paper shows that ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are coordinated, with ESCRTs and ubiquitinated cargo regulating Rab conversion timing.

The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria

The paper identifies ER-mitochondria contact sites as essential for the ER-SURF pathway's role in transferring mitochondrial precursor proteins from the ER to mitochondria.

Bacterial RNA promotes proteostasis through inter-tissuecommunication in C. elegans

The paper shows that bacterial-derived RNA extends healthspan in C. elegans by reducing protein aggregation through inter-tissue communication and systemic RNAi.

Endosomal LRBA regulates the endo-lysosomal pathway

This study identifies LRBA's role in regulating the endosomal-lysosomal pathway by controlling Rab4+ endosome traffic, leading to enlarged endolysosomes in LRBA-deficient patients.

Selective lipid recruitment by an archaeal DPANN symbiont from its host

This study identifies 110 lipid species selectively recruited by an archaeal DPANN symbiont from its host, revealing changes in lipid composition and membrane fluidity.

ATP synthase evolution on a cross-braced dated tree of life

This study reconstructs the evolutionary history of ATP synthase using a cross-braced dated tree of life, showing early divergence of F- and A/V-type lineages and timing of eukaryogenesis.

An evolutionary timescale for Bacteria calibrated using the Great Oxidation Event

This paper uses machine learning and phylogenetic reconciliation to estimate the evolutionary timeline of Bacteria, linking transitions to aerobic lifestyles to the Great Oxidation Event.

The power and limitations of species tree-aware phylogenetics

This paper reviews species tree-aware phylogenetic methods, evaluates their reliability, and discusses their applications and limitations in inferring gene and species trees.

Genetic analysis of rab7 mutants in zebrafish

This study investigates the role of Rab7 genes in zebrafish vascular development, showing their involvement in lumen formation and identifying functional redundancy and maternal contributions.

The parasitic lifestyle of an archaeal symbiont

This study identifies a parasitic lifestyle in a DPANN archaeon that causes host cell lysis, suggesting a predatory-like interaction similar to viruses.

The small GTPase Arf1 regulates ATP synthesis and mitochondria homeostasis by modulating fatty acid metabolism

This study shows that Arf1 regulates fatty acid metabolism, affecting mitochondrial homeostasis and ATP synthesis in yeast.

A novel live cell imaging assay reveals regulation of endosome maturation

The paper introduces a live-cell imaging assay to study endosome maturation kinetics and identifies Snx1- and Rab11-dependent recycling and Rab conversion-dependent acidification.

Unraveling the critical growth factors for stable cultivation of (nano-sized) Micrarchaeota

This study reports the enrichment of a stable co-culture of Micrarchaeota with its host and identifies dependencies on host-derived metabolites for growth.

The C. elegans PTCHD homolog PTR-4 is required for proper organization of the pre-cuticular apical extracellular matrix

This study identifies PTR-4 as essential for organizing the pre-cuticular apical extracellular matrix in C. elegans, with defects in cuticle formation and function in its absence.

An estimate of the deepest branches of the tree of life from ancient vertically-evolving genes

The paper estimates the deepest branches of the tree of life by analyzing marker genes and shows that current methods underestimate the Archaea-Bacteria branch length due to substitutional saturation and poor model fit.

Decapping complex is essential for functional P-body formation and is buffered by nuclear localization

The paper shows that the decapping complex is essential for P-body formation and that its nuclear localization buffers its function in mRNA decay.

Undinarchaeota illuminate the evolution of DPANN archaea

The paper reconstructs genomes of Undinarchaeota, a new DPANN archaeal lineage, and analyzes their phylogenetic placement and potential gene exchange with hosts.

Patched regulates lipid homeostasis by controlling cellular cholesterol levels

This study identifies PTC-3 as a cholesterol transporter in C. elegans, showing that its loss causes cholesterol accumulation, ER defects, and lipid metabolism issues, which are rescued by reducing dietary cholesterol.

Local translation of yeast ERG4 mRNA at the endoplasmic reticulum requires the brefeldin A resistance protein Bfr1

This study shows Bfr1p binds ERG4 mRNA and facilitates its translation at the ER, while also playing a role in ploidy control and chromosome segregation.

Marine sediments illuminate Chlamydiae diversity and evolution

The paper reports high abundance and diversity of novel Chlamydiae lineages in marine sediments, revealing their ecological significance and genomic diversity.

New Asgard archaea capable of anaerobic hydrocarbon cycling

The paper identifies a new archaeal phylum, Helarchaeota, capable of anaerobic hydrocarbon oxidation, based on genomic analysis of deep-sea sediment metagenomes.

FERARI: a novel tether involved in endocytic recycling

This study identifies FERARI as a conserved tethering complex involved in Rab11 recycling pathways at sorting endosomes, coordinating fusion and pinching activities.

An archaeal symbiont-host association from the deep terrestrial subsurface

The paper identifies a host-symbiont relationship between two uncultivated archaea in a deep aquifer, showing co-occurrence and metabolic interdependence.

Virus genomes from deep sea sediments expand the ocean megavirome and support independent origins of viral gigantism

The paper reports the discovery of new NCLDV genomes from deep-sea sediments, expanding the ocean megavirome and supporting independent origins of viral gigantism.

Asymmetric Distribution of Glucose Transporter mRNA Provides Growth Advantage

The paper shows that HXT2 mRNA is asymmetrically localized in yeast cells, providing a growth advantage to daughter cells during nutrient shifts.

Complex evolutionary history of translation Elongation Factor 2 and diphthamide biosynthesis in Archaea and parabasalids

The paper investigates the evolutionary history of diphthamide biosynthesis and EF-2 in archaea and parabasalids, revealing multiple losses of diphthamide production and functional divergence in EF-2.

Context-dependent deposition and regulation of mRNAs in P-bodies

The paper identifies mRNA subsets associated with P-bodies under stress and shows how Puf5p regulates their decay or storage depending on cellular conditions.