FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
A. Orthwein, S. Findlay, J. Heath, V. Luo, A. Malina, Z. Li, A. Samiei, E. S. Cheyou, M. Karam, H. Bagci, D. Rahat, D. Grapton, E. G. Lavoie, C. Dove, H. Khaled, , H. Kuasne
This study identifies FAM35A as a novel REV7 effector that promotes NHEJ and restricts HR by limiting DNA end resection at DSBs.
bioRxiv · Jul 11, 2018Cancer Biology