Z. Li

Amplified genome editing by in vivo editor production

This study demonstrates that in vivo delivery of genome editing enzymes can be amplified through cell-to-cell transfer, significantly increasing editing efficiency in mice.

The evolution of sexual dichromatism in a large radiation of landfowl: Re-examining female-biased selection in Wallace's model

The paper re-examines Wallace's model of female-biased selection on sexual dichromatism using Phasianidae landfowl, finding negative correlation with female color contrast and support for nest predation's role.

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

Aeon: an open-source platform to study the neural basis of ethological behaviours over naturalistic timescales

Aeon enables long-term study of ethological behaviours in mice with simultaneous brain activity recording and provides a unified data format for analysis.

Pangenome and comparative genomics analysis reveal patterns of quorum sensing and antimicrobial resistance in Salmonella Lineages from African Food Chains

This study analyzes Salmonella genomes from African food chains to identify patterns of antimicrobial resistance and quorum sensing, revealing lineage-specific genes and geographic diversity.

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

Environmental modulators of algae-bacteria interactions at scale

The paper investigates how environmental factors like pH, nutrient availability, and carbon source affect algae-bacteria interactions using a high-throughput microfluidic platform and statistical analysis.

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

The m6A Reader ECT1 Mediates Seed Germination via the DAG2-ECT1-PHYB Regulatory Cascade in Arabidopsis

This study identifies ECT1 as an m6A reader protein that promotes seed germination in Arabidopsis through a DAG2-ECT1-PHYB regulatory cascade involving transcriptional and post-transcriptional control.

Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis

This paper engineers a plant virus to deliver a compact CRISPR-Cas system for transgene-free germline editing in Arabidopsis.

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

BOOST: a robust ten-fold expansion method on hour-scale

BOOST is a rapid expansion microscopy method that achieves ~10x linear expansion in 90 minutes using microwave-assisted chemistry, improving throughput for various biological specimens.

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

Cloud-Connected Patch-Worn Auscultation Device for Chest Sound Monitoring

The paper describes a wearable device for chest sound monitoring that transmits 10-second recordings via Bluetooth-Low-Energy and includes noise reduction features.

CREB REGULATES FOXP3+ST-2+ TREGS WITH ENHANCED IL-10 PRODUCTION

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells

This study introduces hydroporation as a scalable and efficient method for delivering CAR-T cells, achieving higher yields and viability compared to traditional methods.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

Hydrolysis of palm kernel meal fibre using a newly isolated Bacillus subtilis F6 with high mannanase activity

This study isolates a Bacillus subtilis strain with high mannanase activity to hydrolyze palm kernel meal fibre, reducing neutral detergent fibre content by 10%.

An organoid platform reveals MEK-PARP co-targeting to enhance radiation response in rectal cancer

The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Prominin-1 null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy, and dysmorphic retinal pigment epithelium.

This study shows that prom1-null Xenopus laevis develop subretinal drusenoid-like deposits and retinal degeneration, indicating RPE dysfunction precedes photoreceptor loss.

Structures of PSI-FCPI from Thalassiosira pseudonana in high light provide convergent evolution and light-adaptive strategies in diatom FCPIs

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.

The HCoV-HKU1 N-terminal domain binds a wide range of 9-O-acetylated sialic acids presented on different glycan cores

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.