Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation
R. J. Harris, M. Heer, M. D. Levasseur, T. N. Cartwright, B. Weston, J. L. Mitchell, J. M. Coxhead, L. Gaughan, L. Prendergast, D. Rico, J. M. G. Higgins
The paper investigates the interaction between H3K4me3 and H3T3ph during mitosis, finding that H3T3ph does not prevent H3K4 reader binding, challenging the histone code hypothesis in this context.
bioRxiv · Feb 28, 2023Cell Biology