Pharmacology & ToxicologybioRxiv
Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumor eEF1A antagonist SR-A3
H. Wang, H. Yang, M. Holm…·J. Taunton
This study synthesizes and characterizes SR-A3, a stereoisomer of a natural product, showing enhanced binding kinetics and therapeutic efficacy in a mouse lymphoma model.
DOI 10.1038/s41557-022-01039-3