H. Yang

c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application

PanCanSurvPlot provides a web tool for large-scale pan-cancer survival analysis with 215 datasets, 45,000 samples, and customizable survival plots.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

The Plasmodiophora brassicae effector PbEGF1 manipulates plant immunity and regulate primary infection

This study identifies PbEGF1, an effector from Plasmodiophora brassicae, which manipulates plant immunity and promotes infection by degrading BnNHL13.

Biochar Modulates Wheat Root Metabolome and Rhizosphere Microbiome in a Feedstock-dependent Manner

This study investigates how different biochar feedstocks affect wheat root metabolome and rhizosphere microbiome, finding that feedstock type has a greater impact than application rate.

B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements

This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.

BOOST: a robust ten-fold expansion method on hour-scale

BOOST is a rapid expansion microscopy method that achieves ~10x linear expansion in 90 minutes using microwave-assisted chemistry, improving throughput for various biological specimens.

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans

The paper identifies host genetic factors influencing anti-PD-1 response in mice and humans by mapping QTLs and finding a core gene network with prognostic value in human tumors.

Body size and light environment modulate flight speed and saccadic behavior in free flying Drosophila melanogaster

The paper examines how body size and light environment affect flight speed and saccadic behavior in Drosophila melanogaster, finding that visual deficits in smaller flies lead to flight changes.

HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells

This study develops anti-HLA-E-VL9 antibodies that enhance NK and CD8+ T cell cytotoxicity against HIV-infected cells by blocking NKG2A/CD94 interactions and promoting ADCC.

Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

This study shows PM curvature promotes ER-PM contact formation in cardiomyocytes via junctophilin-EHD interactions.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

Plio-Pleistocene decline of mesic forest underpins diversification in a clade of Australian Panesthia cockroaches

This study uses phylogenetic analysis to show that Plio-Pleistocene aridification drove speciation and niche shifts in Australian Panesthia cockroaches.

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state

Single cell RNA sequencing of bladder cancer subtypes identified a CA125+ cell state linked to aggressive features and TM4SF1 as a therapeutic target.

The chlamydial transcriptional regulator Euo is a key switch in cell form developmental progression but is not involved in the committed step to the formation of the infectious form.

This study shows that ectopic expression of the chlamydial transcriptional regulator Euo arrests developmental progression at an early Intermediate Body stage but does not affect the formation of the infectious Elementary Body.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

plantMASST - Community-driven chemotaxonomic digitization of plants

The paper curates LC-MS/MS data from plant extracts to create a taxonomically focused database for exploring plant-derived molecules.

Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

This study investigates nearest-neighbor cooperativity in TRAP by engineering dTRAP variants and using cryo-EM and thermodynamic analyses to reveal structural and thermodynamic mechanisms of ligand binding cooperativity.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms.

This study identifies distinct gene expression patterns in Chlamydia trachomatis developmental stages and shows T3SS genes are cell type restricted.

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

This paper engineers Escherichia coli Nissle 1917 to block antibiotic resistance gene transfer using a type I CRISPR-Cas system, showing efficacy in vitro and in zebrafish.

Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH

The paper identifies L3HYPDH as an IFN-stimulated gene that inhibits EV71 replication by targeting its IRES-mediated translation.