Imatinib overrides taxane resistance by selective inhibition of novel CLIP1 variant obstructing the microtubule pore
K. Kita, P. V. Thakkar, G. Galletti, N. Madhukar, E. V. Navarro, I. Barasoain, H. V. Goodson, D. Sackett, J. F. Diaz, O. Elemento, M. A. Shah, P. Giannakakou
The paper identifies a novel CLIP-170 variant, CLIP-170S, that causes taxane resistance in gastric cancer and shows imatinib can reverse this resistance by selectively inhibiting CLIP-170S.
bioRxiv · Nov 11, 2019 · PreprintCancer Biology