Cancer BiologybioRxivPreprint
Imatinib overrides taxane resistance by selective inhibition of novel CLIP1 variant obstructing the microtubule pore
K. Kita, P. V. Thakkar, G. Galletti…·P. Giannakakou
The paper identifies a novel CLIP-170 variant, CLIP-170S, that causes taxane resistance in gastric cancer and shows imatinib can reverse this resistance by selectively inhibiting CLIP-170S.
DOI 10.1101/838334