Taxanes act as vascular disrupting agents and increase rate of metastasis when combined with anti-angiogenic therapy
R. Nandigama, M. Kallius, K. Hemmen, D. Shaoli, J. Pinnecker, D. Ascheid, V. Burkhard, H. Ali, J. Rainer, D. Scheld, S. Herterich, A. Zernecke, O. Penack, S. Diller, K. Camphausen, , E. Henke
This study shows that taxanes act as vascular disrupting agents, causing vascular collapse and hypoxia, and when combined with anti-angiogenic therapy, increase metastasis.
bioRxiv · Jul 18, 2022 · PreprintCancer Biology