H. Ali

An array of Zymoseptoria tritici effectors suppress plant immune responses

The paper identifies Zymoseptoria tritici effectors that suppress plant immune responses by screening libraries and analyzing structural predictions.

The astrovirus N-terminal nonstructural protein anchors replication complexes to the perinuclear ER membranes

This study identifies di-arginine motifs in the N-terminal domain of astrovirus nsP1a that mediate ER retention and replication complex formation.

State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia

The paper uses transcriptome-based state-transition models to predict CML disease progression and treatment response using time-sequential blood samples from mice.

Exploring Microbial Diversity and Functional Potential along the Bay of Bengal Coastline in Bangladesh: Insights from Amplicon Sequencing and Shotgun Metagenomics

This study analyzes microbial diversity and functional potential along the Bay of Bengal coastline using amplicon sequencing and shotgun metagenomics, revealing dominant taxa and functional genes in two sites.

Perception and Readiness Towards Inter-Professional Education Among Different Health Care Disciplines at Khyber Medical University Peshawar

This study assesses perception and readiness towards interprofessional education among healthcare students at Khyber Medical University, finding strong positive correlations between perception and readiness.

Design And Optimization Studies Of Tablet In Tablet Formulation Of Diclofenac And Misoprostol: Application Of Response Surface Methodolgy And Compressional Behaviour Strategy

This study develops compression-coated tablets of diclofenac and misoprostol using response surface methodology and evaluates their quality and stability.

Attenuation hotspots in neurotropic human astroviruses

This study identifies attenuation hotspots in neurotropic human astroviruses by analyzing dispensable regions in the capsid-coding region and confirms their role in neuronal attenuation using recombinant viruses.

Taxanes act as vascular disrupting agents and increase rate of metastasis when combined with anti-angiogenic therapy

This study shows that taxanes act as vascular disrupting agents, causing vascular collapse and hypoxia, and when combined with anti-angiogenic therapy, increase metastasis.

The wheat head blight pathogen Fusarium graminearum recruits facultative endohyphal bacteria from the soil, making the fungal-bacterial holobiont nitrogen-fixing and increasing the fungal pathogenicity

This study shows that the wheat pathogen Fusarium graminearum can acquire nitrogen-fixing facultative endohyphal bacteria from soil, enhancing its pathogenicity.

Whole genome regulatory effect of MoISW2 and consequences for the evolution of rice plant pathogenic fungus Magnaporthe oryzae

The paper investigates the regulatory role of MoISW2 in Magnaporthe oryzae, showing its impact on gene expression variability and niche-determinant genes, with implications for fungal evolution.

Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response.

This paper identifies STING1 activation by heme from Plasmodium-infected erythrocytes as a key driver of cerebral malaria through type I IFN and CXCL10-mediated inflammation.

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity

This paper shows that SARS-CoV-2 Spike protein activates TMEM16F in platelets, enhancing pro-coagulant activity and thrombosis, which is inhibited by Niclosamide and Clofazimine.

Collagen Pre-strain Discontinuity at the Cartilage - Bone Interface

The paper identifies a pre-strain gradient in collagen fibrils at the bone-cartilage interface, linking it to biomechanical resilience and osteoarthritis progression.

Identifying Priority Landscapes for Conservation of Snow Leopards in Pakistan

This study identifies priority landscapes for snow leopard conservation in Pakistan using species distribution modeling and connectivity analysis.

Megakaryocytes, erythropoietic and granulopoietic cells express CAL2 antibody in myeloproliferative neoplasms carrying CALR gene mutations

The paper validates the use of CAL2 antibody for detecting CALR mutations in MPNs through immunohistochemistry and confirms its specificity to mutated CALR in ET and MDS/MPN.

Aceclofenac Fast Dispersible Tablet Formulations: Effect of different concentration levels of Avicel PH102 on the compactional, mechanical and drug release characteristics

This study develops fast dispersible aceclofenac tablets using Avicel PH102, mannitol, and ac-di-sol, finding that formulation FB provides optimal mechanical strength and rapid drug release.

A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression.

This paper develops an antibody targeting ICOS that improves the TEFF:TReg ratio and induces tumour regression in preclinical models.

Inhibitor of apoptosis, IAP, genes play a critical role in the survival of HIV-infected macrophages

This study shows that SMAC-mimetics induce apoptosis in HIV-infected macrophages by targeting IAPs, suggesting IAP modulation as a strategy for eliminating viral reservoirs.

Parallel evolution of frog antimicrobial peptides produces identical conformations but subtly distinct membrane and antibacterial activities

This study compares two frog antimicrobial peptides, temporin L and aurein 2.5, to understand their differing antibacterial activities despite similar structures.