Lymph node fibroblast phenotypes and immune crosstalk regulated by Podoplanin activity
S. Makris, Y. Hari-Gupta, J. A. Cantoral-Rebordinos, V. G. Martinez, H. L. Horsnell, A. Benjamin, I. Cinti, D. Shewring, N. Nguyen, M. Jovancheva, C. M. de Winde, A. Denton, S. E. Acton
This study shows that Podoplanin deletion in fibroblastic reticular cells increases inflammatory signaling and disrupts stromal-immune crosstalk in lymph nodes.
bioRxiv · Dec 1, 2022Immunology