Crosstalk between Rac and Rho GTPase activity mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles.
S. Nanda, A. Calderon, T.-T. Duong, J. Koch, A. Sachan, X. Xin, D. Solouk, Y.-W. Wu, P. Nalbant, L. Dehmelt
The paper investigates Rac and Rho GTPase crosstalk mediated by Arhgef11 and Arhgef12, showing they coordinate cell protrusion-retraction cycles during migration.
bioRxiv · Feb 20, 2023Cell Biology