Existing host range mutations constrain further emergence of RNA viruses
L. Zhao, M. Seth Pasricha, D. Stemate, A. Crespo-Bellido, J. Gagnon, S. Duffy
This paper shows that pre-existing host range mutations in RNA viruses restrict the genetic pathways available for further host range expansion, using bacteriophage phi6 as a model system.
bioRxiv · Aug 17, 2018Microbiology