L. Zhao

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

This study identifies that Δ133p53α and Δ160p53α isoforms exert a dominant-negative effect on p53 by co-aggregating with full-length p53, disrupting its function.

Dynamic regulation of H2A.Zub and H3K27me3 by ambient temperature in plant cell fate determination

The paper shows that low temperature restores developmental defects in PRC2 mutants by promoting H2A.Zub deposition at embryonic genes, compensating for H3K27me3 loss and silencing these genes for post-germination development.

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

A Kruppel-like factor establishes cellular heterogeneity during schistosome tegumental maintenance

The paper identifies klf4's role in maintaining tegumental cell heterogeneity in schistosomes through bulk and single-cell RNAseq, showing its necessity for lineage maintenance and molecular balance.

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and Foe

This study identifies KLF6 as a key driver of endothelial dysfunction in pulmonary arterial hypertension, showing its role in promoting vascular remodelling and angioproliferative lesions.

The fully activated open state of KCNQ1 controls the cardiac 'fight-or-flight' response

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers

This paper introduces a graph-based model to identify druggable vulnerabilities in solid cancers, finding 43 novel targets by leveraging cooperativity in molecular networks.

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

Comparative Single Cell Analysis of Transcriptional Bursting Reveals the Role of Genome Organization on de novo Transcript Origination

The paper identifies a core gene set for cross-species cell type classification in Drosophila and shows genome organization influences transcriptional bursting and de novo gene origination during spermatogenesis.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Nor-LAAM loaded PLGA Microparticles for Treating Opioid Use Disorder

This paper develops sustained-release nor-LAAM-loaded PLGA microparticles for OUD treatment, showing prolonged drug release and reduced fentanyl choice and withdrawal in rats.

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

Engineering One-Signal Activated TILs with CD3ζ-CD28 Chimeras Optimizes the Antitumor Efficacy of TIL-Based Immunotherapy

This paper engineers one-signal-activated TILs with CD3ζ-CD28 chimeras to enhance antitumor efficacy in immunotherapy.

Overexpression of PpGL2 from Prunus persica enhanced soybean drought tolerance

This study overexpresses PpGL2 in soybean to improve drought tolerance, showing reduced oxidative stress and enhanced growth under drought conditions.

Targeting CD19 for the treatment of autoimmune with a novel T cell engager

This study develops YK012, a T cell engager targeting CD19, showing potential for treating autoimmune diseases with improved efficacy and reduced side effects compared to existing therapies.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

Genetic Toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling

This study develops new genetic tools for Photorhabdus and Xenorhabdus, including SEVA-based expression vectors and CRISPR/Cpf1 genome editing systems, enabling efficient natural product profiling.

Flagella are required to coordinately activate competition and host colonization factors in response to a mechanical signal

This study identifies flagella as mechanosensors in Vibrio fischeri that coordinate activation of competition and host colonization factors in response to viscosity changes.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

Nerve Growth Factor Receptor Limits Inflammation to Promote Remodeling and Repair of Osteoarthritic Joints

This study identifies NGFR's role in limiting inflammation to promote joint remodeling and repair in osteoarthritis by modulating NF-κB and BMP-SMAD1 signaling.

Camel milk affects serum metabolites by modulating the intestinal microflora

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

Improved bladder cancer antitumor efficacy with a recombinant BCG that releases a STING agonist

This study evaluates a recombinant BCG strain that releases a STING agonist, showing improved antitumor efficacy in bladder cancer models compared to wild-type BCG.

Changes in physicochemical properties and microbial community succession during leaf stacking fermentation

This study examines changes in physicochemical properties and microbial communities during leaf stacking fermentation, identifying key metabolites and microbial interactions.

The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

This study investigates the evolutionary origin of sex peptide (SP) and sex peptide receptor (SPR) interactions using ancestral sequence reconstruction, AlphaFold2, and molecular dynamics simulations.

Host tracheal and intestinal microbiomes inhibit Coccidioides growth in vitro

This study shows that host tracheal and intestinal microbiomes inhibit Coccidioides growth in vitro, but antibiotic depletion reduces this inhibition, suggesting microbiome disruption may worsen fungal infections.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Avoidance of hydrogen sulfide is modulated by external and internal states in C. elegans

This study investigates how C. elegans modulates its avoidance response to hydrogen sulfide through environmental and internal factors, revealing HIF-1 signaling and ROS dynamics as key regulators.

TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein

This study identifies TRIM72 as a host factor that restricts lyssavirus infection by promoting ubiquitination and proteasomal degradation of the viral matrix protein.

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

The paper identifies sphingolipids as regulators of synphilin-1 inclusion body maturation and detoxification in yeast and mammalian cells.