FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
B. R. Wilde, N. Chakraborty, N. Matulionis, S. Hernandez, D. Ueno, M. E. Gee, E. D. Esplin, K. Ouyang, K. Nykamp, B. Shuch, H. R. Christofk
This paper functionally characterizes FH variants of uncertain significance and identifies purine salvage pathway dependence as a targetable vulnerability in FH-deficient kidney cancer.
bioRxiv · Aug 15, 2022Cancer Biology