S. Hernandez

Internet-connected cortical organoids for project-based stem cell and neuroscience education

This paper describes using internet-connected cortical organoids to enhance STEM education through project-based learning in two university courses.

Modulation of neuronal activity in cortical organoids with bioelectronic delivery of ions and neurotransmitters

This study introduces a bioelectronic method to modulate neuronal activity in cortical organoids using ion and neurotransmitter delivery, demonstrating precise control over network activity.

Open-loop lab-on-a-chip technology enables remote computer science training in Latinx life sciences students

This paper demonstrates that lab-on-a-chip technology combined with internet-based project-based learning can effectively train Latinx students in computational biology and increase their interest in STEM careers.

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.

Chemo-sEVs release in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function

This study shows that cisplatin-resistant ovarian cancer cells release chemo-sEVs regulated by lysosomal function, with RAB27A silencing restoring lysosomal function and reducing sEVs secretion.

FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer

This paper functionally characterizes FH variants of uncertain significance and identifies purine salvage pathway dependence as a targetable vulnerability in FH-deficient kidney cancer.

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

Improving Lab Culture Through Self-Assessment: A Case Study

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

The proteasomal deubiquitinating enzyme PSMD14 regulates macroautophagy by controlling Golgi-to-ER retrograde transport

The paper identifies PSMD14 as a regulator of Golgi-to-ER retrograde transport and macroautophagy through its role in K63-Ub chain deubiquitination.