Membrane Topology of UbiA Prenyltransferase Domain-Containing Protein-1 (UBIAD1), a Novel Regulator of Cholesterol Homeostasis
B. Johnson, D.-J. Jun, R. DeBose-Boyd
This study determines the membrane topology of UBIAD1 using cysteine derivatization and protease protection assays to understand how GGpp modulates its intracellular trafficking and ERAD of HMGCR.
bioRxiv · Mar 2, 2023 · PreprintBiochemistry