B. Johnson

Gut and oral microbial community characterization from women with breast cancer, women with ductal carcinoma in situ, and healthy women reveals differences in gut but not oral microbiota

This study compares gut and oral microbiota in women with breast cancer, ductal carcinoma in situ, and healthy controls, finding significant gut microbiota differences but not oral ones.

Phylochemical mapping of natural products onto the plant tree of life using text mining and large language models.

This paper maps natural products onto the plant tree of life using text mining and large language models, revealing lineage-specific distributions and demonstrating automation potential.

Organ specific microenvironmental MR1 expression in cutaneous melanoma

The paper examines organ-specific microenvironmental MR1 expression in cutaneous melanoma using zebrafish models and imaging techniques, finding differential immune responses and metabolism in brain versus skeletal metastases.

Macrophage mediated mesoscale brain mechanical homeostasis mechanically imaged via optical tweezers and Brillouin microscopy in vivo

The paper uses optical tweezers and Brillouin microscopy to study brain mechanical properties in larval zebrafish, showing macrophages influence tissue mechanics during development.

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts

The paper identifies a complex of TMEM24 and C2CD2 with band 4.1 proteins at ER/PM junctions, showing their role in lipid transport and cell-cell contact regulation.

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

This study identifies a novel interaction between SARS-CoV-2 NSP3 and FMRPs, showing that this interaction is critical for viral replication and disease progression.

Membrane Topology of UbiA Prenyltransferase Domain-Containing Protein-1 (UBIAD1), a Novel Regulator of Cholesterol Homeostasis

This study determines the membrane topology of UBIAD1 using cysteine derivatization and protease protection assays to understand how GGpp modulates its intracellular trafficking and ERAD of HMGCR.

Estimating single cell clonal dynamics in human blood using coalescent theory

This paper estimates the net growth rate of hematopoietic clones in human blood using coalescent theory, finding that clones with multiple driver mutations grow faster and are linked to earlier MPN diagnosis.

Identification of two β-cell subtypes by 7 independent criteria

The paper identifies two distinct β-cell subtypes, βHI and βLO, using seven independent criteria and shows that H3K27me3 dosage regulates their ratio in vivo.

Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis

This study shows that Leptospermum extract (QV0) reduces pleural mesothelioma tumour growth in vitro and in vivo by inducing mitochondrial dysfunction and apoptosis without adverse effects.

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection

This study compares memory B cell responses after Delta and Omicron BA.1 breakthrough infections versus mRNA vaccine doses, finding that Delta infection boosts overall memory B cell potency and breadth, while Omicron infection only enhances strain-specific responses.

Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens

This study compares humoral immune responses to different SARS-CoV-2 vaccination regimens, finding differences in antibody and memory B cell responses and neutralizing breadth against variants.

Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine

This study compares memory B cell responses after single-dose Ad26.COV2.S and mRNA vaccines, finding lower quantities but comparable neutralizing quality in Ad26.COV2.S recipients.

Increased Potency and Breadth of SARS-CoV-2 Neutralizing Antibodies After a Third mRNA Vaccine Dose

This study shows that a third mRNA vaccine dose increases the potency and breadth of SARS-CoV-2 neutralizing antibodies, particularly against the Omicron variant, through the expansion and evolution of memory B cells.

Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

Zebrafish xenografts to isolate unique human breast cancer metastatic cell populations

This paper develops a zebrafish xenograft model to isolate and study human breast cancer metastatic cells, identifying genes and pathways involved in invasion.

CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes

This study shows that Gastrin-producing mesenchymal stem cells protect NOD mice from type 1 diabetes by preserving beta-cell mass and modulating immune responses.

Colonic epithelial adaptation to EGFR-independent growth induces induces chromosomal instability and is accelerated by prior injury

This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.

Role of T cells in intrauterine administration of activated peripheral blood mononuclear cells in recurrent implantation failure.

This study evaluates how T cell activation with PHA/hCG affects Th2, Treg, and Th17 cells in RIF patients, showing increased anti-inflammatory cells and altered endometrial immunomodulation.

Branching and extinction in evolutionary public goods games

This study investigates how cooperation and defection emerge in nonlinear local public goods games through evolutionary branching and population size effects.

Abundance and nuclear antigen reactivity of intestinal and fecal Immunoglobulin A in lupus-prone mice at younger ages correlate with the onset of eventual systemic autoimmunity

The paper examines IgA abundance and nuclear antigen reactivity in intestinal and fecal samples of lupus-prone mice, finding correlations with systemic autoimmunity onset.

Assessing anaerobic gut fungal (Neocalliamstigomycota) diversity using PacBio D1/D2 LSU rRNA amplicon sequencing and multi-year isolation

This study develops and applies D1/D2 LSU rRNA amplicon sequencing using PacBio to assess anaerobic gut fungal diversity in herbivores, identifying novel lineages and improving culturability.

Pretreatment with yeast derived complex dietary-polysaccharide leads to suppressed gut inflammation, altered microbiota composition and increased immune regulatory short-chain fatty acid production in C57BL/6 mice

This study shows that pretreatment with yeast-derived beta-glucans reduces DSS-induced colitis in mice by altering gut microbiota and increasing SCFA production, but loses efficacy when administered during disease onset.