An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn's disease
Tatiana A. Karakasheva, Clara Morral, Yusen Zhou, Jingya Qui, Xinyi E. Chen, Gloria E. Soto, Shaneice K. Nettleford, Olivia T. Hix, Daana M. Roach, Alyssa M. Laguerta, Anusha Thadi, Rachael M. Edwards, Daniel Aleynick, Sarah Weinbrom, Elizaveta Borodyanskaya, , Kathryn E. Hamilton
The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.
Cellular and Molecular Gastroenterology and Hepatology · Oct 21, 2025Peer-reviewedPhysiology