Whole-Proteome Screening and Multi-Modal Profiling of Antigen-Specific CD4+ T Cells at Single-Cell Resolution
Rongyu Zhang, Qi Jin, Michaela McKasson, Jongchan Choi, Vanessa Gutiérrez, Conor Brennan, Sunga Hong, William Chour, Rachel H. Ng, Jingyi Xie, Dan Yuan, Andrew Webster, Simranjeet K. Sidhu, Abby Anderson, Daniel Chen, , James R. Heath
The paper develops a high-throughput platform to profile antigen-specific CD4+ T cells at single-cell resolution, identifying immunogenic features and functional heterogeneity in viral and cancer contexts.
bioRxiv · Apr 21, 2025 · PreprintBioengineering