NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice
Daniel Egbase, Sophie R. Sayers, Naila Haq, Jithu James Varghese, Vesela Gesheva, Sreya Bhattacharya, Jay Kynaston, Ella-Louise Hubber, Lorna I. F. Smith, Timothy J. Pullen, Henry Gerdes, Vivian K. Lee, David Hopkins, Min Zhao, Yee Cheah, , Paul Caton
This study shows that inhibiting NAMPT reduces inflammation and beta-cell damage in T1D by blocking cytokine-mediated immune responses in mice.
bioRxiv · Jan 14, 2025 · PreprintCell Biology