Genome Editing With Targeted Deaminases
Luhan Yang, Adrian Briggs, Wei Leong Chew, Prashant Mali, Marc Guell, John Aach, Daniel Goodman, David Cox, Yinan Kan, Emal Lesha, Venkataramanan Soundararajan, Feng Zhang, George Church
This paper introduces targeted deaminases for site-specific C-to-T genomic edits without DNA cleavage, achieving 13% efficiency in E. coli and 2.5% in human cells with reduced toxicity.
Nature Communications · Nov 2, 2016Peer-reviewedBioengineering