Author

Marc Guell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Organism:human· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Adrian Briggs· 1 shared Alexandra GonzalesiD· 1 shared Barry L. Wanner· 1 shared Cameron L. GardneriD· 1 shared Christopher J. Gregg· 1 shared Conor K. CamplissoniD· 1 shared Daniel Goodman· 1 shared David CoxiD· 1 shared

Activity by Year

2016-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

Adrian Briggs

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2 papers

Recent·Most cited

Genome Editing With Targeted Deaminases

Luhan Yang, Adrian Briggs, Wei Leong Chew, Prashant Mali, Marc Guell, John Aach, Daniel Goodman, David Cox, Yinan Kan, Emal Lesha, Venkataramanan Soundararajan, Feng Zhang, George Church

This paper introduces targeted deaminases for site-specific C-to-T genomic edits without DNA cleavage, achieving 13% efficiency in E. coli and 2.5% in human cells with reduced toxicity.

Nature Communications · Nov 2, 2016Peer-reviewedBioengineering

Assembly of Radically Recoded E. coli Genome Segments

Julie E. Norville, Cameron L. Gardner, Eduardo Aponte, Conor K. Camplisson, Alexandra Gonzales, David K. Barclay, Katerina A. Turner, Victoria Longe, Maria Mincheva, Jun Teramoto, Kento Tominaga, Ryota Sugimoto, James E. DiCarlo, Marc Guell, Eriona Hysolli, , George M. Church

This paper introduces CAGE 2.0, a platform for scarless assembly of recoded E. coli genome segments, enabling efficient and safe genome engineering.

bioRxiv · Aug 31, 2016 · PreprintSynthetic Biology