Endocannabinoid ligands (CBD, Δ9THC, and Terpenes) inhibit excitability of mouse dorsal root ganglion neurons and exhibit synergistic inhibitory effects
Hedaythul Choudhury, Mazin Nicola, Barnaby W. Greenland, Daniel Guest, John Spencer, Andrew Dilley
This study shows that CBD, THC, and terpenes inhibit mouse DRG neuron excitability, with synergistic effects suggesting potential for non-opioid analgesics.
bioRxiv · Jul 22, 2026 · PreprintPharmacology & Toxicology