Zinc excess promotes lysosome remodeling by activating HLH-30/TFEB through the action of the high zinc sensor HIZR-1.
Ciro A. Cubillas, Hanwenheng Liu, Krupa Deshmukh, Adelita D. Mendoza, Daniel L. Schneider, Daniel Herrera, Chen Zhao, John T. Murphy, John Edwards, Abhinav Diwan, Kerry Kornfeld
The paper identifies a zinc-regulated genetic pathway in C. elegans that activates lysosome remodeling through HIZR-1 and HLH-30/TFEB to enhance zinc detoxification.
bioRxiv · Feb 24, 2026 · PreprintGenetics