Author

Krupa Deshmukh

Washington University in St. Louis

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Genetics· 1

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Organism:C. elegans· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

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Abhinav DiwaniD· 1 shared Adelita D. MendozaiD· 1 shared Chen Zhao· 1 shared Ciro A. CubillasiD· 1 shared Daniel Herrera· 1 shared Daniel L. SchneideriD· 1 shared Hanwenheng LiuiD· 1 shared John Edwards· 1 shared

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Abhinav DiwanORCID

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1 paper

Recent·Most cited

GeneticsbioRxivPreprintFeb 24, 2026

Zinc excess promotes lysosome remodeling by activating HLH-30/TFEB through the action of the high zinc sensor HIZR-1.

Ciro A. Cubillas, Hanwenheng Liu, Krupa Deshmukh…·Kerry Kornfeld

The paper identifies a zinc-regulated genetic pathway in C. elegans that activates lysosome remodeling through HIZR-1 and HLH-30/TFEB to enhance zinc detoxification.

DOI 10.64898/2026.02.22.707197

C. elegansstatistical model

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