Multimodal epi-mode 3D quantitative phase and fluorescence microscopy enables supervised volumetric virtual fluorescence in bulk tissue
Zhenmin Li, Srinidhi Bharadwaj, Aaron D. Silva Trenkle, Daniel Houston, Kyan Nguyen, Nimai Ponna, Jacob P. Callaway, Gabriel A. Kwong, Francisco E. Robles
This paper introduces a multimodal microscope that uses a cGAN to generate virtual fluorescence images from phase contrast data, enabling virtual histological staining of bulk tissues.
bioRxiv · Oct 29, 2026 · PreprintBioengineering