Author

Daniel Leon

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Benjamin NicholsoniD· 3 shared Weijie GuoiD· 3 shared Yuxuan MiaoiD· 3 shared Alexander T. PearsoniD· 2 shared Ari Joseph RosenbergiD· 2 shared Diana Bolotin· 2 shared Everett E. VokesiD· 2 shared Evgeny IzumchenkoiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Benjamin NicholsonORCID

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Author profile →

3 papers

Recent·Most cited

Integrated analysis of stemness-associated immune modulatory circuits in squamous cell carcinomas

Weijie Guo, Daniel Leon, Jingyun Luan, Audrey Gang, Xuejie Huang, Benjamin Nicholson, Karolina Dorosz, Yinhan Stacey Zhao, Sarra Grimshaw, Diana Bolotin, Mark William Lingen, Everett E. Vokes, Alexander T. Pearson, Ari Joseph Rosenberg, Le Shen, , Yuxuan Miao

The paper identifies SOX2 as a master regulator of immune modulatory circuits in tumor-initiating stem cells, enabling immunosuppressive myeloid cell development.

bioRxiv · Apr 6, 2026 · PreprintCancer Biology

Comparative single cell analysis of wound and cancer identifies the metabolic dialogues between tumor initiating stem cells and macrophages

Weijie Guo, Daniel Leon, Benjamin Nicholson, Jianwen Que, Yuxuan Miao

This study compares single-cell RNA sequencing data from wound healing and cancer to identify metabolic differences between tumor-associated macrophages and wound-associated macrophages, highlighting SOX2High stem cells as key regulators.

bioRxiv · Apr 6, 2026 · PreprintCancer Biology

Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche

Weijie Guo, Jingyun Luan, Xuejie Huang, Daniel Leon, Sophie Gang, Benjamin Nicholson, Breanna Bertacchi, Diana Bolotin, Mark William Lingen, Alexander T. Pearson, Evgeny Izumchenko, Ari Joseph Rosenberg, Nishant Agrawal, Everett E. Vokes, Siwakorn Punyawatthananukool, , Yuxuan Miao

This study identifies tumor-initiating cells that modulate neutrophil plasticity to create a protective niche, preventing immunotherapy effectiveness.

Cancer Cell · Dec 4, 2025Peer-reviewedCancer Biology