Jianwen Que

This study compares single-cell RNA sequencing data from wound healing and cancer to identify metabolic differences between tumor-associated macrophages and wound-associated macrophages, highlighting SOX2High stem cells as key regulators.

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

The paper maps the functional fitness landscape of the MYC locus, identifies an ultraconserved RNA element critical for MYC function, and shows it can be targeted to kill MYC-addicted cancer cells.

The paper develops scG2P to jointly capture DNA mutations and mRNA transcripts in single cells, revealing clonal architectures and phenotypes in aged esophageal tissue.

This study shows STAT3 is essential for esophageal progenitor cell development and epithelial morphogenesis in humans, but not in mice.

This study shows that diverse training data improves basecalling accuracy for novel RNA modifications in nanopore sequencing.

The paper identifies two specialized pericyte subtypes in pulmonary capillaries using Higd1b as a marker and shows their distinct functions and responses to hypoxia.

This study identifies a SOX2-CCL2-IL1 pathway that drives immune suppression in precancerous epithelial dysplasia, promoting malignant transformation.

This paper introduces an iterative method to improve nanopore sequencing basecalling accuracy for therapeutic RNA quality control, enabling precise analysis of modified RNAs.

The paper develops vascularized macrophage-islet organoids to study immune-mediated β cell pyroptosis during viral infection and identifies TNFSF12-TNFRSF12A as a key mechanism.

This paper adapts nanopore sequencing basecalling models for modification detection using incremental learning and anomaly detection, achieving single-molecule and single-nucleotide resolution across multiple species and modification types.

The paper develops a spatiotemporal multi-omics platform and machine-learning tool to manufacture hPSC-derived esophageal mucosa.

The paper identifies the Foxa2 lineage's role in lung development and demonstrates that conditional complementation of this lineage can generate a whole lung in mice.

This study identifies the role of Wnt/Fgf crosstalk in tracheal basal progenitor cell specification through genetic ablation experiments in mouse models.