Elevated ferritin as a companion biomarker of myeloid-driven inflammation in RNP/Sm co-positive, treatment-resistant SLE endotype
Muhammad Ruhul Amin Shipa, Claire Beesley, Daniel McClusky, Vincent Guichard, S Clare Chung, Laura A. Cooney, Derek William Gilroy, Michael R. Ehrenstein
This paper identifies an RNP/Sm co-positive SLE endotype with myeloid-driven inflammation, hyperferritinaemia, and treatment resistance, suggesting targeted therapies are needed.
bioRxiv · Feb 14, 2026 · PreprintImmunology