Author

Daniel Smith

Ginkgo Bioworks, Inc. (United States)Primary ORCID profile (0000-0002-5867-9613 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Daniel SmithiD1 paper · The University of Queensland

Biology Disciplines

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Evolutionary Biology· 1 Genetic & Genomic Medicine· 1 Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Abigail PageiD· 1 shared Ahmed El-KishkyiD· 1 shared Alexandra Alfenjar· 1 shared Alexus A. Smith· 1 shared Alicia Byrn· 1 shared Alvaro R. Bautista-AyalaiD· 1 shared Alycia Wong· 1 shared Alyssa Tran· 1 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperEvolutionary Biology

Abigail PageORCID

Author profile →

4 papers

Recent·Most cited

SNX13 and SNX14 interorganelle tethers suppress lysosome membrane damage and neurodegeneration

Kaitlynn Gov, Vanessa Sánchez, Emma Reynolds, Caroline Bickerton, Teresa Jimenez, Sanghee Yun, Ipsita Chakraborty, Raunaq Deo, Daniel Smith, Thomas Roulé, Blessy Paul, Sonakshi Srivastava, Amelia J. Eisch, Ophir Shalem, Xilma Rosa Ortiz-Gonzalez, , Naiara Akizu

This study identifies SNX13 and SNX14 as proteins that maintain lysosome membrane integrity and prevent neurodegeneration by supporting lipid homeostasis and repair mechanisms.

medRxiv · Oct 23, 2026 · PreprintGenetic & Genomic Medicine

Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis

Alexus A. Smith, Edmund L. Wong, Ronan C. Donovan, Brad Chapman, Ryan Harry, Pooyan Tirandazi, Paulina Kanigowska, Elizabeth A. Gendreau, Robert H. Dahl, Michal Jastrzebski, Jose E. Cortez, Christopher Bremner, José C. Morales Hemuda, James Dooner, Ian Graves, , Reshma P. Shetty

This paper demonstrates an LLM-driven autonomous lab that reduces the cost of cell-free protein synthesis by 40% and increases titer by 27% through iterative optimization.

bioRxiv · Feb 5, 2026 · PreprintSynthetic Biology

High-resolution maps of hunter-gatherer social networks reveal human adaptation for cultural exchange

Andrea Bamberg Migliano, Abigail Page, Jesus Gómez-Gardeñes, Sylvain Viguier, Mark Dyble, James Thompson, Nikhill Chaudhary, Gul Deniz Salali, Daniel Smith, Janis Strods, Vito Latora, Ruth Mace, Lucio Vinicius

The paper maps social networks of hunter-gatherers to show that non-kin friendships enhance cultural exchange and are an ancestral adaptation.

bioRxiv · Feb 19, 2016 · PreprintEvolutionary Biology

Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank

Andrew M McIntosh, Lynsey S Hall, Yanni Zeng, Mark James Adams, Jude Gibson, Ella Wigmore, Maria Pujils-Fernandez, Archie I Campbell, Toni-Kim Clarke, Caroline Hayward, Christopher Haley, David Porteous, Ian Deary, Daniel Smith, Barbara Nicholl, , Lynne J Hocking

This study identifies genetic and environmental factors contributing to chronic pain and its link to major depressive disorder using data from Generation Scotland and UK Biobank.

bioRxiv · Jan 21, 2016 · PreprintGenomics