A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection
Cornelia Blume, Claire L. Jackson, Cosma Mirella Spalluto, Jelmer Legebeke, Liliya Nazlamova, Franco Conforti, Jeanne‐Marie Perotin, Martin Frank, John Butler, Max Crispin, Janice L. Coles, James Thompson, Robert A. Ridley, Lareb S. N. Dean, Matthew Loxham, , Vito Mennella
The paper identifies a novel short ACE2 isoform expressed in respiratory epithelia that is upregulated by interferon and RNA virus infection but not SARS-CoV-2, and shows reduced SARS-CoV-2 binding affinity.
Nature Genetics · Jan 11, 2021Peer-reviewedMolecular Biology