Immunotherapy with Pro-regenerative Macrophages from Embryonic Stem Cells Ameliorate Osteoarthritis via TNFAIP3-Mediated Chondroprotection
Zhumei Zhuang, Zicong Liu, Hang Su, Wei Sun, Qiuwen Zhu, Jingyi Xu, Jinghua Fang, Liying Li, Danni Shen, Xiaohui Zou, Hendrik Marks, Xianzhu Zhang, Hua Liu, Ouyang Hong Wei
This study generates pro-regenerative macrophages from hESCs to treat OA, showing they reduce inflammation and restore cartilage via TNFAIP3 signaling.
bioRxiv · Dec 15, 2025 · PreprintImmunology