Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasis
Kyu Hwan Shim, Yong Ran, Danny Ryu, Brenda D. Moore, Yeeun Yook, Pooneh Amin, Xuefei Liu, Kazi Farhana Afroz, Caroline Martin, Mihir Beheray, Wangchen Tsering, Lei Liu, Madison E. Platt, Blaine Roberts, Nicholas T. Seyfried, , Todd Eliot Golde
This study shows that Syndecan-4 has both HS-dependent and HS-independent effects on Aβ amyloid homeostasis, reducing amyloid deposition in a mouse model.
bioRxiv · Aug 25, 2026 · PreprintNeuroscience