Hepatic Deletion of X-box Binding Protein 1 in Farnesoid X Receptor Null Mice Leads to Enhanced Liver Injury
Xiaoying Liu, Mahmoud G. Khalafalla, Chuhan Chung, Yevgeniy Gindin, Susan C. Hubchak, Brian E. LeCuyer, Alyssa A. Kriegermeier, Danny Zhang, Wei Qiu, Xianzhong Ding, Deyu Fang, Richard Green
This study investigates the role of the UPR in FXR null mice, finding that hepatic XBP1 activation provides protection against liver injury and tumor development.
Journal of Lipid Research · Sep 24, 2022Peer-reviewedMolecular Biology