Author

Daphne Baker

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Agnel J. SfeiriD· 1 shared Caleb A. LareauiD· 1 shared Craig B. ThompsoniD· 1 shared Dana Pe’eriD· 1 shared Ed ReznikiD· 1 shared Elim Choi· 1 shared Emily DeBitetto· 1 shared Ignas MasilionisiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Agnel J. SfeirORCID

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1 paper

Recent·Most cited

Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria

Yi Fu, Max Land, Tamar Kavlashvili, Ruobing Cui, Min‐Soo Kim, Emily DeBitetto, Toby Lieber, Keun Woo Ryu, Elim Choi, Ignas Masilionis, Rahul Saha, Meril T. Takizawa, Daphne Baker, Marco Tigano, Caleb A. Lareau, , Agnel J. Sfeir

This paper develops a method to engineer specific mtDNA deletions in human cells using end-joining machinery and targeted endonucleases, revealing a 75% heteroplasmy threshold for mitochondrial dysfunction.

Cell · May 1, 2025Peer-reviewedMolecular Biology